Mary Mallon spreads typhoid fever wherever she goes, and Cleopatra’s younger sister Arsinoe schemes her way in and out of power in Ancient Egypt.

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Navy officer Douglas Hegdahl outwits his captors when he’s taken as a POW in North Vietnam, and Florence Nightingale revolutionizes the field of nursing.

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Marina Raskova forms an all-women air force regiment to fight Nazis in World War II, and smuggler James J. Andrews hijacks a Confederate train for the Union.

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Martha Mitchell leaks the Watergate scandal to the press before Deep Throat does, and the Citizens’ Commission to Investigate the FBI stages an epic break-in.

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Forest service ranger Ed Pulaski saves 40 men from a forest fire, and Ted Patrick rescues teenagers from the psychological grip of the Children of God cult.

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Hedy Lamarr designs the first modern airplane wing, Eartha Kitt's activism provokes the ire of Lady Bird Johnson, and Alexis Pulaski's poodle becomes a huge star.

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Lead Belly records songs with John Lomax that change the face of music, John Lennon and Yoko Ono almost get deported, and Sam Cooke writes “A Change Is Gonna Come.”

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Larry Walters pilots a balloon-suspended lawn chair, Phineas Gage survives an iron rod to the brain, and the Greenbrier Ghost’s testimony is used in court.

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Colonial gossip columnist James Callender winds up dead, a Hollywood producer dies on a celebrity-filled yacht, and Ken McElroy is murdered after terrorizing a Missouri town.

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Journalist Maurine Dallas Watkins writes a play about Chicago’s infamous Murderesses’ Row, and Mata Hari goes from exotic dancer to double agent during World War I.

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John F. Kennedy’s doctor administers him meth for his back pain, and Dr. John C. Lilly takes LSD while studying the intelligence of dolphins.

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A student tunnels beneath the Berlin Wall, Edie Windsor topples the Defense of Marriage Act, and John Wojtowicz robs a bank to pay for his wife’s gender reassignment surgery.

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Bessie Coleman is America’s first black woman pilot, and the students of the Little Rock Nine integrate a high school following the Brown v. Board of Education decision.

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Moses Fleetwood Walker faces racism in the 19th century MLB, the Chicago White Sox throw the World Series, and the Callaghan sisters inspire the film "A League of Their Own."

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John Muir convinces Teddy Roosevelt to preserve Yosemite, journalist Marjory Stoneman Douglas fights to protect the Everglades, and Native American activists occupy Alcatraz.

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Will Ferrell and Seth Rogen star in this episode about how teenage writer Mary Shelley created her legendary novel, “Frankenstein.”

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